李尚泽，男，重庆市武隆人，博士，副教授

2008年获得成都理工大学/电子科技大学工学及管理学学士学位，2014年获得武汉大学理学博士学位，2014-2017年美国西北大学Feinberg School of Medicine博士后研究员，2017-2020武汉大学第二临床学院/生命科学学院任职助理研究员，2021年至今重庆大学医学院任副教授，硕士生导师。

 实验室主要从事抗病毒天然免疫信号转导、炎症反应与肿瘤发病机理研究。以基因敲除及敲入技术，构建基因突变细胞及小鼠，并通过构建动物疾病模型探索基因在调节免疫稳态及肿瘤发生发展中的功能及机制。共发表文章32篇，文章引用超过1300次, H指数19。在Nature Communications、Cancer Research、Biochimica et biophysica acta、Cell death and differentiation、Cancer letters及Oncogene等杂志以第一作者或通讯作者（含共同）发表SCI论文共计16篇，累计影响因子120.9。

热忱欢迎具有坚强毅力，自我驱动力，有志于探索生命科学未知领域及疾病发病机制的研究生报考，希望以绵薄之力与你一起共同重塑未来。

研究方向：

1，天然免疫信号转导动态调控，抗病毒

2，炎症应答稳态，可控化调节

3，炎症及自免疫疾病发病机制

4，消化及泌尿系统肿瘤发病机制

教学课程：

1、分子医学前沿

2、医学学术规范与研究生论文写作指导

代表性论文（*，第一；#，通讯）

1. Li, S. Z.*, Zhang, Z. Y.*, Chen, J.*, Dong, M. Y., Du, X. H., Gao, J., Shu, Q. P., Li, C., Liang, X. Y., Ding, Z. H., Du, R. L., Wang, J. & Zhang, X. D. (2022) NLK is required for Ras/ERK/SRF/ELK signaling to tune skeletal muscle development by phosphorylating SRF and antagonizing the SRF/MKL pathway, Cell Death Discov. 8, 4. (IF: 5.214)

2. Tao, H., Liao, Y., Yan, Y., He, Z., Zhou, J., Wang, X., Peng, J., Li, S.^# & Liu, T.^# (2021) BRCC3 Promotes Tumorigenesis of Bladder Cancer by Activating the NF-kappaB Signaling Pathway Through Targeting TRAF2, Front Cell Dev Biol. 9, 720349. (IF: 6.684)

3. Zhang, H. H., Li, C., Ren, J. W., Liu, L., Du, X. H., Gao, J., Liu, T.^# & Li, S. Z.^# (2021) OTUB1 facilitates bladder cancer progression by stabilizing ATF6 in response to endoplasmic reticulum stress, Cancer Sci. 112, 2199-2209. (IF: 6.716)

4. Li, C.*, Li, S. Z.*, Huang, X. C., Chen, J., Liu, W., Zhang, X. D., Song, X. M. & Du, R. L. (2021) PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis, Genes Dis. 8, 838-848. (IF: 7.103)

5. Zhang, M. H., Zhang, H. H., Du, X. H., Gao, J., Li, C., Shi, H. R. & Li, S. Z. (2020) UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate the NF-kappaB pathway, Oncogene. 39, 322-333. (IF: 9.867)

6. Li, S. Z.*^{, #}, Shu, Q. P.*, Song, Y., Zhang, H. H., Liu, Y., Jin, B. X., Liuyu, T. Z., Li, C., Huang, X. C., Du, R. L., Song, W., Zhong, B. & Zhang, X. D.^# (2019) Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response, Nat Commun. 10, 3233. (IF: 14.919)

7. Li, S.*, Fong, K. W.*, Gritsina, G., Zhang, A., Zhao, J. C., Kim, J., Sharp, A., Yuan, W., Aversa, C., Yang, X. J., Nelson, P. S., Feng, F. Y., Chinnaiyan, A. M., de Bono, J. S., Morrissey, C., Rettig, M. B. & Yu, J. (2019) Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer, Cancer Res. 79, 2580-2592. (Cover letter) (IF: 12.701)

8. Zhao, H., Pan, W. M., Zhang, H. H., Song, Y., Chen, J., Xiang, Y., Gu, B., Li, S. Z.^#, Du, R. L. & Zhang, X. D.^# (2019) Cancer testis antigen 55 deficiency attenuates colitis-associated colorectal cancer by inhibiting NF-kappaB signaling, Cell Death Dis. 10, 304. (IF: 8.469)

9. Li, S.*^{, #}, Hu, L.*, Li, J., Zhu, J., Zeng, F., Huang, Q., Qiu, L., Du, R. & Cao, R. (2019) Design, synthesis, structure-activity relationships and mechanism of action of new quinoline derivatives as potential antitumor agents, Eur J Med Chem. 162, 666-678. (IF: 6.514)

10. Li, S. Z.*^{, #}, Ren, J. W.*, Fei, J., Zhang, X. D. & Du, R. L. (2019) Cordycepin induces Baxdependent apoptosis in colorectal cancer cells, Mol Med Rep. 19, 901-908. (IF: 2.952)

11. Li, S. Z.*, Zeng, F.*, Li, J., Shu, Q. P., Zhang, H. H., Xu, J., Ren, J. W., Zhang, X. D., Song, X. M. & Du, R. L. (2018) Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1, Cancer Lett. 431, 43-53. (IF: 8.679)

12. Zhang, H. H.*, Li, S. Z.*, Zhang, Z. Y., Hu, X. M., Hou, P. N., Gao, L., Du, R. L. & Zhang, X. D. (2014) Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage, Cell Death Differ. 21, 1656-63. (IF: 15.828)

13. Li, S. Z.*, Zhang, H. H.*, Liang, J. B., Song, Y., Jin, B. X., Xing, N. N., Fan, G. C., Du, R. L. & Zhang, X. D. (2014) Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKbeta, Biochim Biophys Acta. 1843, 1365-72. (IF: 4.739)

14. Li, S. Z.*, Song, Y.*, Zhang, H. H., Jin, B. X., Liu, Y., Liu, W. B., Zhang, X. D. & Du, R. L. (2014) UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer, Sci Rep. 4, 6910. (IF: 4.379)

15. Li, S. Z.*, Zhang, H. H.*, Zhang, J. N., Zhang, Z. Y., Zhang, X. F., Zhang, X. D. & Du, R. L. (2013) ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis, Biochem Biophys Res Commun. 437, 325-30. (IF: 3.575)

16. Liu, Y., Li, S., Zhang, H., Wan, Z., Zhang, X. & Du, R. (2012) A one-step cloning method for the construction of somatic cell gene targeting vectors: application to production of human knockout cell lines, BMC Biotechnol. 12, 71. (IF: 2.563)

其它论文

1. Hu, X. T., Xing, W., Zhao, R. S., Tan, Y., Wu, X. F., Ao, L. Q., Li, Z., Yao, M. W., Yuan, M., Guo, W., Li, S. Z., Yu, J., Ao, X. & Xu, X. (2020) HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer, J Exp Clin Cancer Res. 39, 270.

2. Song, B., Park, S. H., Zhao, J. C., Fong, K. W., Li, S., Lee, Y., Yang, Y. A., Sridhar, S., Lu, X., Abdulkadir, S. A., Vessella, R. L., Morrissey, C., Kuzel, T. M., Catalona, W., Yang, X. & Yu, J. (2019) Targeting FOXA1-mediated repression of TGF-beta signaling suppresses castration-resistant prostate cancer progression, J Clin Invest. 129, 569-582.

3. Zhang, Q., Zhang, Z. Y., Du, H., Li, S. Z., Tu, R., Jia, Y. F., Zheng, Z., Song, X. M., Du, R. L. & Zhang, X. D. (2019) DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer, Cell Death Differ. 26, 2300-2313.

4. Fong, K. W., Zhao, J. C., Kim, J., Li, S., Yang, Y. A., Song, B., Rittie, L., Hu, M., Yang, X., Perbal, B. & Yu, J. (2017) Polycomb-Mediated Disruption of an Androgen Receptor Feedback Loop Drives Castration-Resistant Prostate Cancer, Cancer Res. 77, 412-422.

5. Xue, X., Yang, Y. A., Zhang, A., Fong, K. W., Kim, J., Song, B., Li, S., Zhao, J. C. & Yu, J. (2016) LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer, Oncogene. 35, 2746-55.

6. Yang, Y. A., Zhao, J. C., Fong, K. W., Kim, J., Li, S., Song, C., Song, B., Zheng, B., He, C. & Yu, J. (2016) FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function, Nucleic Acids Res. 44, 8153-64.

7. Fan, J. D., Lei, P. J., Zheng, J. Y., Wang, X., Li, S., Liu, H., He, Y. L., Wang, Z. N., Wei, G., Zhang, X., Li, L. Y. & Wu, M. (2015) The selective activation of p53 target genes regulated by SMYD2 in BIX-01294 induced autophagy-related cell death, PLoS One. 10, e0116782.

8. Zhang, Z. Y., Li, S. Z., Zhang, H. H., Wu, Q. R., Gong, J., Liang, T., Gao, L., Xing, N. N., Liu, W. B., Du, R. L. & Zhang, X. D. (2015) Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1beta-stimulated C/EBP signaling pathway, Mol Cell Biol. 35, 778-88.

9. Song, W., Liu, W., Zhao, H., Li, S., Guan, X., Ying, J., Zhang, Y., Miao, F., Zhang, M., Ren, X., Li, X., Wu, F., Zhao, Y., Tian, Y., Wu, W., Fu, J., Liang, J., Wu, W., Liu, C., Yu, J., Zong, S., Miao, S., Zhang, X. & Wang, L. (2015) Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway, Nat Commun. 6, 8022.

10. Zhang, X. F., Li, K. K., Gao, L., Li, S. Z., Chen, K., Zhang, J. B., Wang, D., Tu, R. F., Zhang, J. X., Tao, K. X., Wang, G. & Zhang, X. D. (2015) miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPbeta, Oncotarget. 6, 4144-58.

11. Yu, Z., Zhou, X., Wang, W., Deng, W., Fang, J., Hu, H., Wang, Z., Li, S., Cui, L., Shen, J., Zhai, L., Peng, S., Wong, J., Dong, S., Yuan, Z., Ou, G., Zhang, X., Xu, P., Lou, J., Yang, N., Chen, P., Xu, R. M. & Li, G. (2015) Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres, Dev Cell. 32, 68-81.

12. Li, T., Guan, J., Li, S., Zhang, X. & Zheng, X. (2014) HSCARG downregulates NF-kappaB signaling by interacting with USP7 and inhibiting NEMO ubiquitination, Cell Death Dis. 5, e1229.

13. Hu, B., Li, S., Zhang, X. & Zheng, X. (2014) HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation, Nucleic Acids Res. 42, 5582-93.

14. Huang, Z., Li, S., Song, W., Li, X., Li, Q., Zhang, Z., Han, Y., Zhang, X., Miao, S., Du, R. & Wang, L. (2013) Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/beta-catenin pathway by down-regulating Dickkopf-1 (DKK1), PLoS One. 8, e70077.

15. Wang, X., Zhu, K., Li, S., Liao, Y., Du, R., Zhang, X., Shu, H. B., Guo, A. Y., Li, L. & Wu, M. (2012) MLL1, a H3K4 methyltransferase, regulates the TNFalpha-stimulated activation of genes downstream of NF-kappaB, J Cell Sci. 125, 4058-66.

16. Du, R., Li, S. & Zhang, X. (2011) A modified plasmid vector pCMV-3Tag-LIC for rapid, reliable, ligation-independent cloning of polymerase chain reaction products, Anal Biochem. 408, 357-9.

基金

1. 国家自然科学基金：UCHL3去泛素化稳定PPARγ在膀胱癌发生发展中的作用

机制研究（81902844），2020.01-2022.12，主持

2. 中央高校基本科研业务费医工融合项目：CLK2调节病毒诱导的炎症因子风暴研究（2021CDJYGRH-004），2021.07-2023.06，主持

3.国家科技支撑计划（基因工程大鼠模型的研发与示范2012BAI02B00），2012.01-2014.12，参与

4. 国家科技支撑计划（2012BAI39B03），2012.01-2014.12，参与

5. 国家重大科学研究计划（2011CB944404），2011.01-2015.12，参与